KMID : 1123920140280030317
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Korean Journal of Oriental Physiology and Pathology 2014 Volume.28 No. 3 p.317 ~ p.321
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Inhibition of A¥â42 Fibrillation and Toxicity with ¥â-Asarone
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Kim Ji-A
Lee Chul-Won Lee Boo-Kyun Lee Jang-Cheon An Won-Gun
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Abstract
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Amyloid-¥â protein (A¥â) is a pathological component of Alzheimer¡¯s disease (AD) by participating in the senile plaque formation in the patient¡¯s brain. Although the exact mechanism of A¥â toxicity is not fully elucidated, it is considered to be closely related to its fibrillation process. For prevention of AD, recent studies have suggested various small molecules which inhibit A¥â fibrillation. In this report, ¥â-asarone found in acorus plant has been investigated as an anti-amyloid molecule. ¥â-Asarone was demonstrated to prevent in vitro fibrillation of A¥â by inducing the oligomer formation that obviously decreased cytotoxicity. Therefore, ¥â-asarone could be suggested as an inhibitory agent of A¥â fibrillation and toxicity, which would help us not only to understand underlying principle of amyloidogenesis mechanism but also to develop a controlling strategy toward AD.
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KEYWORD
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Amyloidogenesis, Amyloid-¥â, Neurodegenerative disorders, Alzheimer's disease, ¥â-Asarone, Acorus gramineus soland
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